The Hahn Lab specializes in the development of tissue engineered replacements for diseased small-caliber arteries and osteochondral tissues and in the regeneration of chronically scarred tissue. Our tissue regeneration strategy focuses on engineering scaffold material properties to stimulate progenitor cells to promote tissue-specific healing following implantation. This approach avoids pre-implantation cell/construct culture and increases the translational potential of the engineered constructs. However, it also requires that the selected biomaterial scaffolds intrinsically promote desired progenitor cell lineage progression even in the continued presence of environmental signals promoting disease or fibrosis. A more recent thrust of our research program is the development of tissue engineered disease models (e.g. for osteoarthritis), with a focus on the influence of aberrant macrophage and peripheral nerve activation in propagating particular disease states.